In October 1911, the touring Abbey Theatre presented Synge's Playboy of the Western World at the Plymouth; in the audience were W. B. Yeats, Isabella Stewart Gardner and Rose Fitzgerald Kennedy.
Later performers included Henry Jewett, Bill "Bojangles" Robinson, 8-year-old Sammy Davis, Jr., and Bette Davis.
The Shubert Organization of New York bought the Plymouth in 1927 and used it largely for tryouts of plays headed for New York or going on tour, and for some long run performances.